The best cute nickname for girls with the twelve zodiac signs in English is a subjective matter and varies from person to person.

When it comes to giving a nickname, it is important to consider the personality traits of the individual and what suits them the most. Here are some suggestions for cute nicknames for girls based on the different zodiac signs:

1. Aries - Little Firecracker: Aries women are known for their fiery and passionate personalities. This nickname complements their energy and their spark.

2. Taurus - Sweetie Pie: Taurus women are often sweet-natured and genuine. This nickname plays into their kindness and warmth.

3. Gemini - Chatty Cathy: Geminis love to communicate and socialize. This nickname highlights their outgoing and talkative nature.

4. Cancer - Lovebug: Cancer women are sensitive and caring. This nickname highlights their loving and nurturing qualities.

5. Leo - Queen Bee: Leo women love to be in charge and are often the center of attention. This nickname suits their bold and confident nature.

6. Virgo - Brainiac: Virgo women are intelligent and detail-oriented. This nickname plays into their analytical and methodical nature.

7. Libra - Cutie Patootie: Libra women are charming and graceful. This nickname complements their refined and elegant qualities.

8. Scorpio - Little Vixen: Scorpio women are passionate and mysterious. This nickname highlights their alluring and seductive qualities.

9. Sagittarius - Adventure Girl: Sagittarius women love to travel and explore the world. This nickname suits their adventurous and free-spirited nature.

10. Capricorn - Boss Lady: Capricorn women are hardworking and goal-oriented. This nickname complements their ambitious and determined qualities.

11. Aquarius - Rebel Girl: Aquarius women are independent and unconventional. This nickname highlights their unique and non-conformist nature.

12. Pisces - Dreamer: Pisces women are imaginative and creative. This nickname suits their dreamy and artistic qualities.

In summary, the best cute nickname for girls with the twelve zodiac signs in English is subjective and depends on the individual's personality. The above suggestions can be used as a starting point to find the perfect nickname that truly suits them.